I had a friend a few years ago that had been diagnosed with a plethora of mental issues which left him in a cycle of self neglect. I am in no way blaming him, but it was clear the effects of no physical exercise (at least, anything too strenuous), absence of socializing IRL and a poor diet left him in a much more... regressed state than he could've been, I just wish he could've at least had one period where he was hitting all those 'targets', but alas, mental health does not play nice. I had my own battles, and I think the biggest thing for me is getting enough sleep.