I wouldn't mind Matt Mercer doing more than one role.
However, I will admit that I'll be a bit disappointed if he does both Xander and Ryoma. I'd like to see a bit more variety and there are surely enough actors that can pull off at least one of the big brothers.
As for Elise and Sakura, I ain't got a clue. Neither of them sounded familiar to me.
Edit: Also, Hana sounded like either Lauren Landa or Michelle Ruff to me.