I think my set up will be; Normal, Classic, Resets, Grinding if necessary, Nohr.
The grinding question threw me off because I assumed there wouldn't be any in this game but if it's there and I'm having trouble then I'll abuse it. Usually my first run is just to view the story, not give much thought into the best units to choose or skills but just enjoy myself with a new game. Any time after that I'll go with Hard.
Nohr just intrigues me more than Hoshido, the characters shown so far look nice (mostly) and some of them in particular stand out to me (Nyx's hair pls). Oh and I have no problems with the awakening child expies, actually I kind of like having some familiar faces. Sev and Inigo were among the units I liked the most too so that's a bonus for me.