I'm thinking they will release a proper trailer for the Virtual Release of Pokemon Red/Blue/Yellow and talk a bit about the distributions as well as that fancy New 3DS Bundle. I'm hoping they announce a new main series Pokemon game as well (Or, I know this is a longshot, Pokemon Conquest 2, please?). I'm expecting some news for Pokken, as a bunch of info just got released in Japan.
^I Second that a Pokemon Direct should come :)
I'm actually hoping they release some of the earlier Fire Emblems on the 3DS Eshop, to get people into the hype for Fates. With the hype for Fates, they are probably going to announce when Corrin and Bayonetta will hit the shop to be purchased to play in Smash Bros. I also feel they will squeeze out one more English Fates trailer to hype it up even more.
Like mentioned above, they are probably going to talk about GIR #FE for the English release and probably give a solid date. They probably will announce a fancy bundle for Bravely Second for the English release, and tie up any other loose ends on games. Oh, and more news on Zelda U and Twilight Princess HD.
Lastly, they will probably announce some new titles to keep people interested for the first to second quarter of the year. Not sure what these could be, as Nintendo has surprised us before. It would be nice to finally get a sequel to Kid Icarus Uprising, but that probably won't happen.